{"definition":"A protein that is a translation product of an evolutionary-related gene with core domain composition consisting of an N-terminal Protein kinase domain (Pfam:PF00069), a Rho Binding domain (Pfam:PF08912), and a PH domain (Pfam:PF00169) and a Phorbol esters/diacylglycerol binding domain (C1 domain) (Pfam:PF00130) at the C-terminus. Rho-associated protein kinases are mediators of many cellular processes by being effectors of the small GTP-binding protein Rho.","identifier":"000000024","name":"Rho-associated protein kinase","prefix":"pr","providers":{"biolookup":"http://biolookup.io/pr:000000024","bioportal":"https://bioportal.bioontology.org/ontologies/PR/?p=classes&conceptid=http://purl.obolibrary.org/obo/PR_000000024","bioregistry":"https://bioregistry.io/pr:000000024","default":"https://proconsortium.org/app/entry/PR:000000024","miriam":"https://identifiers.org/PR:000000024","n2t":"https://n2t.net/pr:000000024","obofoundry":"http://purl.obolibrary.org/obo/PR_000000024","ols":"https://www.ebi.ac.uk/ols/ontologies/pr/terms?iri=http://purl.obolibrary.org/obo/PR_000000024"},"query":"pr:000000024","relations":[{"relation_identifier":"subClassOf","relation_prefix":"rdfs","target_identifier":"000000001","target_prefix":"pr"}],"success":true,"synonyms":["RHO-ASSOCIATED, COILED-COIL CONTAINING PROTEIN KINASE (PTHR22988:SF3)"],"xrefs":[{"provenance":"pr","xref_identifier":"PIRSF037568","xref_prefix":"pirsf"}]}